Amphotericin B lipid complex for neonatal invasive candidiasis
نویسندگان
چکیده
منابع مشابه
Amphotericin B lipid complex for neonatal invasive candidiasis.
This study describes the safety and efficacy of amphotericin B lipid complex (ABLC) in 11 neonates with systemic Candida infections. Nine of the 11 improved clinically, and eight of nine evaluable patients had a mycological cure with ABLC. Creatinine levels improved or did not significantly change in eight of the 11 patients.
متن کاملCaspofungin was as effective as amphotericin B for invasive candidiasis.
P a t i e n t s 239 patients > 18 years of age who had ≥ 1 positive candida culture from blood or another sterile site in the past 4 days, and ≥ 1 clinical sign of infection in the past 2 days (fever, hypothermia, or hypotension) or signs of inflammation at a candida-infected site. Exclusion criteria included suspected endocarditis, osteomyelitis, or meningitis; and receipt of antifungal therap...
متن کاملComparison of caspofungin and amphotericin B for invasive candidiasis.
BACKGROUND Caspofungin is an echinocandin agent with fungicidal activity against candida species. We performed a double-blind trial to compare caspofungin with amphotericin B deoxycholate for the primary treatment of invasive candidiasis. METHODS We enrolled patients who had clinical evidence of infection and a positive culture for candida species from blood or another site. Patients were str...
متن کاملTreatment of neonatal candidiasis with liposomal amphotericin B.
A liposomal amphotericin B preparation (L-AMP-LRC-1) has been developed and tested successfully in adults by us. This preparation was administered to 23 neonates with candidiasis in an open phase II study. All the 14 assessable patients responded completely to the L-AMP-LRC-1 therapy given at 1 mg/kg for 28 days. Compared to AmBisome, another liposomal formulation of amphotericin B, L-AMP-LRC-1...
متن کاملSafety, tolerance, and pharmacokinetics of amphotericin B lipid complex in children with hepatosplenic candidiasis.
The safety, tolerance, and pharmacokinetics of amphotericin B lipid complex (ABLC) were studied in a cohort of pediatric cancer patients. Six children with hepatosplenic candidiasis (HSC) received 2.5 mg of ABLC/kg of body weight/day for 6 weeks for a total dosage of 105 mg/kg. Mean serum creatinine (0.85 +/- 0.12 mg/dl at baseline) was stable at the end of therapy at 0.85 +/- 0.18 mg/dl and at...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood - Fetal and Neonatal Edition
سال: 2001
ISSN: 1359-2998
DOI: 10.1136/fn.84.2.f131